Keywords: Non-Proton, Neuro, Migraine, Extreme fieldMigraine disproportionately affects women in part due to menstrual migraine, linked to 17β-estradiol deprivation. This study implements 23Na MRI at 21.1 T in female Sprague-Dawley rats to evaluate the impact of estradiol deprivation on widespread sodium increases previously reported in the male model. Ovariectomy was implemented, and animals dosed with controlled estradiol to mimic the natural estrus cycle. It was found that females at physiological estradiol concentrations are resilient to sodium increases in the brainstem and CSF, while estradiol deprivation removes this resiliency. This interaction may play a role in menstrual migraine, and the clinical migraine gap between sexes.
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