Keywords: Non-Proton, MetabolismCMRO2 is an important metric for the evaluation of neurovascular and neurometabolic coupling. However, the degree of coupling between brain activity and CMRO2 remains a matter of debate. In this work, we used 17O-ZTE-MRI at 11.7 T to measure CMRO2 during neuronal activation in the rat primary somatosensory cortex. To improve measurements sensitivity, we acquired data over two consecutive cycles of 17O2 inhalation-washout. We show that a significant functional increase in CMRO2 (+7±5%, p=0.016), and in the rates of metabolized water gain and loss KG (+19±11%, p=0.18) and KL (10±6%, p=0.014) can be detected with good spatial resolution after summation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords