Abstract #4724

Skin Sodium Concentration Measurement Increased with Surface-Coils, Higher Resolution Voxel Reshaping, and Lower Flip-Angles

Jingxuan Zhu¹, Christian Beaulieu¹, Karim Damji¹, and Rob Stobbe¹

¹Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

Synopsis

Keywords: Non-Proton, Body

Non-proton (²³Na) MRI studies have measured greater body tissue (skin) sodium concentration in disorders such as hypertension, diabetes, and chronic kidney disease, but literature values of ~15 mM are well below the 77 mM from atomic absorption spectroscopy. Previous studies have used gradient-echo imaging with long TE=2 ms, knee volume-coils, and large 3×3×30=270 mm³ voxels. Here, short TE=0.1 ms twisted projection imaging is used, and signal loss is progressively lowered with surface coil imaging, reshaped 0.4x4x4 = 6.4 mm³ voxels, and lower 60^o flip-angle excitation, ultimately yielding 42 mM calf skin measurement in 10 young adults.

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