Abstract #4727

Quantitative sodium MRI of the human kidneys at 7T – Before, during and after water load via sliding window evaluation

Anna K. Scheipers^1,2, Armin M. Nagel^1,3, Laurent Ruck³, Lena V. Gast³, Mark E. Ladd^1,2,4, and Tanja Platt¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ³University Hospital Erlangen, Institute of Radiology, Friedrich‐Alexander‐Universität Erlangen‐Nürnberg (FAU), Erlangen, Germany, ⁴Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Synopsis

Keywords: Non-Proton, High-Field MRI, Kidney, Quantitative Imaging

²³Na-MRI is a non-invasive tool for the in-vivo quantification of the tissue sodium concentration (TSC); however, it suffers from low in-vivo signals and short relaxation times. High magnetic field strengths, dedicated hardware and pulse sequences as well as various correction methods contribute to obtaining reliable TSCs. In the presented work we employ a custom-built coil and reference vial setup and perform T₁, B₁⁺ and B₁^- corrections that were validated in phantom measurements. We use a sliding window reconstruction for the quantitative ²³Na-images to investigate the changes in the TSC before, during and after a water load in two healthy volunteers.

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