Abstract #4751

Microstructural Alterations in Schizophrenia evaluated by Multidimensional Diffusion MRI and Inhomogeneous Magnetization Transfer Imaging

Khin Khin Tha¹, Maho Kitagawa², Samo Lasic³, Karin Bryskhe³, Jihun Kwon⁴, Marteen Versluis⁵, and Naoki Hashimoto⁶

¹Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan, ²Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School for Biomedical Science and Engineering, Sapporo, Japan, ³Random Walk Imaging, Lund, Sweden, ⁴Philips Japan, Tokyo, Japan, ⁵Philips Healthcare, Best, Netherlands, ⁶Department of Psychiatry, Hokkaido University Faculty of Medicine, Sapporo, Japan

Synopsis

Keywords: Psychiatric Disorders, Diffusion/other diffusion imaging techniques, schizophrenia, multidimensional diffusionThis prospective study aimed to identify the role of multidimensional diffusion (MDD) MRI and inhomogeneous magnetization transfer (ihMT) imaging, the former reported as capable of quantifying various microstructural diffusion properties and differentiating tissue-specific subparts and the latter as selective to changes in myelin, in underpinning the microstructural brain changes in schizophrenia. Alterations in MDD MRI indices were observed, associated with negative symptoms of schizophrenia. Altered size and shape of cells other than myelin (probably glia or neurons) are thought as coined in the pathophysiological mechanisms.

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