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Abstract #4753

Surface-based morphometric abnormalities in patients with early psychosis: an MP2RAGE-based study at 7T

Zirun Wang1, Yasser Alemán Gómez2, Martine Cleusix2, Raoul Jenni2, Luis Alameda2, Philippe Conus3, Merixell Bach Cuadra4,5, Patric Hagmann6, Kim Q. Do2, and Lijing Xin1
1Animal imaging and technology core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Psychiatry, Center for Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Service of General Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 4Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 5Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6Diagnostic Neuroradiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Early psychosis, First-episode schizophreniaThis study aims to investigate brain cortex alterations in early psychosis patients (n = 42) compared to healthy control subjects (n=35). Surface-based morphometric analysis using MP2RAGE images at 7T revealed significant clusters (corrected p<0.05) where the cortical area and cortex volume in early psychosis patients are reduced compared to healthy controls at the junction of lateral occipital, lingual and peri calcarine region at left hemisphere after permutation multiple comparison correction. Bilateral cortical areas, thickness, and volumes of the patients were reported to be changed at the surface vertex level.

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