Abstract #4753

Surface-based morphometric abnormalities in patients with early psychosis: an MP2RAGE-based study at 7T

Zirun Wang¹, Yasser Alemán Gómez², Martine Cleusix², Raoul Jenni², Luis Alameda², Philippe Conus³, Merixell Bach Cuadra^4,5, Patric Hagmann⁶, Kim Q. Do², and Lijing Xin¹

¹Animal imaging and technology core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Department of Psychiatry, Center for Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Service of General Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁴Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁵Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁶Diagnostic Neuroradiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Early psychosis, First-episode schizophreniaThis study aims to investigate brain cortex alterations in early psychosis patients (n = 42) compared to healthy control subjects (n=35). Surface-based morphometric analysis using MP2RAGE images at 7T revealed significant clusters (corrected p<0.05) where the cortical area and cortex volume in early psychosis patients are reduced compared to healthy controls at the junction of lateral occipital, lingual and peri calcarine region at left hemisphere after permutation multiple comparison correction. Bilateral cortical areas, thickness, and volumes of the patients were reported to be changed at the surface vertex level.

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