Abstract #4754

White and Grey Matter Microstructure Alterations in Early Psychosis and Schizophrenia

Tommaso Pavan^1,2, Yasser Alemán-Gómez^1,2, Raoul Jenni^2,3, Martine Cleusix^2,3, Luis Alameda^2,4, Kim Quang Do Cuenod^2,3, Philippe Conus^2,4, Paul Klauser^2,5, Patric Hagmann^1,2, and Ileana Jelescu^1,2

¹Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ²University of Lausanne (UNIL), Lausanne, Switzerland, ³Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁴General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital (CHUV), Lausanne, Switzerland, ⁵Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Synopsis

Keywords: Psychiatric Disorders, Microstructure, Schizophrenia, Neuroinflammation, Neurodegeneration, Microstructure, Diffusion, White Matter, Grey MatterIn schizophrenia, widespread brain abnormalities are commonly reported but not the microstructure alterations. Here, we investigate brain microstructure during early psychosis and schizophrenia using DKI (in GM & WM), a clinically feasible extension of DTI, and we apply the White Matter Tract Integrity – Watson (WMTI-W, WM only) model. In WM, extensive alterations, consistent with demyelination, were found in early psychosis, while transitioning to chronic schizophrenia, microstructure changes become region-specific as indicated by the two ROI-dependent trends of disease progression found in this cohort. GM showed increased diffusivities and decreased kurtosis, but not widespread as in WM.

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