Keywords: Psychiatric Disorders, Psychiatric Disorders, 7T, MRS, Schizophrenia, Metabolism, GlutamineIt has previously been shown that brain glutamine (Gln) may be elevated is some patients with schizophrenia (Sz), and associated with cognitive deficits. Underlying causes of Gln elevation in Sz are unclear, but may be related to increased blood ammonia (NH3) levels. Brain Gln was measured in 12 subjects (5 Sz, 7 healthy controls (HC)) using 7T MR spectroscopy; brain Gln was found to correlate with blood NH3 levels (p < 0.05). and negatively correlate with measures of cognitive performance. This preliminary study therefore supports the hypothesis linking blood ammonia, brain Gln and cognitive performance.
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