Keywords: Psychiatric Disorders, Brain ConnectivityCerebellar dysfunction appears to be a robust phenomenon in schizophrenia, and stimulation targeted at cerebellum can alleviate some symptoms. However, the causal information flow and longitudinal change of cerebrum-cerebellar connectivity were unclear, limiting the choice of precise stimulation strategies. Using Granger causality analysis, we found decreased excitatory inflow and increased inhibitory outflow were located on different cerebellar functional systems in first-episode schizophrenia and these gradually returned to normal in the context of clinical improvement with ongoing antipsychotic treatment. Our work potentially provides new information to facilitate precision medicine targeted at cerebellum.
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