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Abstract #4757

Disrupted causal connectivity anchored on cerebellum in first-episode medication-naive schizophrenia and restoration after treatment

Xia Wei1, Chunyan Luo1, Qiannan Zhao1, and Su Lui1
1Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University., Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, Brain ConnectivityCerebellar dysfunction appears to be a robust phenomenon in schizophrenia, and stimulation targeted at cerebellum can alleviate some symptoms. However, the causal information flow and longitudinal change of cerebrum-cerebellar connectivity were unclear, limiting the choice of precise stimulation strategies. Using Granger causality analysis, we found decreased excitatory inflow and increased inhibitory outflow were located on different cerebellar functional systems in first-episode schizophrenia and these gradually returned to normal in the context of clinical improvement with ongoing antipsychotic treatment. Our work potentially provides new information to facilitate precision medicine targeted at cerebellum.

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