Abstract #4758

Quantitative Susceptibility Mapping and Polygenic Risk Scores in subjects with unusual and psychotic experiences obtained from the UK Biobank

Marisleydis Garcia-Saborit^1,2,3, Carlos Milovic^3,4, Camilo Villaman⁵, Eduardo Perez-Palma⁶, Gabriela Repetto⁶, Nicolas Crossley^3,7, and Cristian Tejos^1,2,3

¹Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile, ³Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile, ⁴School of Electrical Engineering, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile, ⁵Center for Genomics and Bioinformatics, School of Sciences, Universidad Mayor, Santiago, Chile, ⁶Center for Genetics and Genomics, School of Medicine, Clinica Alemana Universidad del Desarrollo, Santiago, Chile, ⁷Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile

Synopsis

Keywords: Psychiatric Disorders, Brain, dopamine, neuromelanin, geneticsWe evaluated a cohort of subject with unusual and psychotic experiences and control subjects obtained from the UK Biobank, and we studied the relationship between susceptibility (QSM) in deep brain nuclei and polygenic risk scores (PRS) of genetic variants associated to psychosis. Although we found significant differences between patients and controls for QSM and PRS, we did not find any relationship between these two variables.

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