Abstract #4764

The selfish brain – Unaltered brain temperature in the acute state of Anorexia Nervosa

Arne Doose¹, Alexander P. Lin², Tyler Chazan Starr², Katherine M. Breedlove², Jennifer Linn³, and Stefan Ehrlich^1,4

¹Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany, Dresden, Germany, ²Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA USA 02115, Boston, MA, United States, ³Institute of Diagnostic and Interventional Neuroradiology, University Hospital Carl Gustav Carus, Technical University, Dresden, Dresden, Germany, Dresden, Germany, ⁴Eating Disorder Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany, Dresden, Germany

Synopsis

Keywords: Psychiatric Disorders, Spectroscopy, Brain temperatureIn anorexia nervosa (AN) restrictive food intake leads to a slowed metabolism. Brain temperature, can provide information about brain metabolism. Difference between Magnetic Resonance Spectrum peaks (Δ_H20-NAA) provide a proxy for brain temperature in 30 AN and 30 healthy control (HC) participants. We found no group differences in brain temperature between AN/HC. Further, we report no group differences in brain temperature between a subgroup of the AN participants with the lowest BMI/body temperature compared to a subsample with higher BMI/body temperature. The results suggest a prioritization of brain metabolism in AN in line with the selfish brain hypothesis.

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