Abstract #4770

Brain functional network hierarchy and neurochemical correlates in deficit and non-deficit schizophrenia

Chengmin Yang¹, Li Yao¹, Jiajun Liu², Zhipeng Yang², and Su Lui¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China., Chengdu, China, ²College of Electronic Engineering, Chengdu University of Information Technology, Chengdu, P.R. China., Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, GradientsBy combining the brain hierarchy changes and their likely potential molecular signatures, we found that the compression of the cortical hierarchy organization in deficit schizophrenia (NS) and non-deficit schizophrenia (NDS) with neurochemical correlates. The altered functional gradients were spatially positively correlated with the receptor of 5-HT2a in DS patients, while negatively correlated with receptor of D1/2 in NDS patients, which revealed the underlying physiological mechanisms of the heterogeneity in schizophrenia.

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