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Abstract #4812

Repeatability and reproducibility of oxygen-enhanced MRI of the lung at 3 tesla: cross-center, cross-vendor evaluation

Mina Kim1, Sarah H. Needleman1, Josephine H. Naish2,3, Yohn Taylor1, Marta Tibiletti2, James P. B. O’Connor4,5, and Geoff J. M. Parker1,2
1Centre for Medical Image Computing (CMIC), Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 2Bioxydyn Limited, Manchester, United Kingdom, 3BHF Manchester Centre for Heart and Lung Magnetic Resonance Research (MCMR), Manchester, United Kingdom, 4Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 5Division of Radiotherapy and Imaging, Institute of Cancer Research, Manchester, United Kingdom

Synopsis

Keywords: Lung, Contrast Mechanisms, oxygen-enhanced MRIA recently developed protocol with a dual echo RF-spoiled gradient echo acquisition enabled simultaneous measurement of dynamic OE signal change and the substantial ∆R2* effect at 3 tesla. To progress towards clinical translation, we evaluated repeatability and reproducibility across two sites, vendors and time points. Our results demonstrate good repeatability for the quantitative and semi-quantitative indices across time points, consistent signal behaviour and repeatable ∆R2* across two sites and vendors, suggesting potential utility in multi-centre clinical studies. However, echo time dependence should be considered when interpreting percentage signal enhancement.

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