Keywords: Lung, Contrast Mechanisms, oxygen-enhanced MRIA recently developed protocol with a dual echo RF-spoiled gradient echo acquisition enabled simultaneous measurement of dynamic OE signal change and the substantial ∆R2* effect at 3 tesla. To progress towards clinical translation, we evaluated repeatability and reproducibility across two sites, vendors and time points. Our results demonstrate good repeatability for the quantitative and semi-quantitative indices across time points, consistent signal behaviour and repeatable ∆R2* across two sites and vendors, suggesting potential utility in multi-centre clinical studies. However, echo time dependence should be considered when interpreting percentage signal enhancement.
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