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Abstract #4813

3D Free-Breathing Ultrashort Echo Time (UTE) 1H Ventilation Compared with Hyperpolarized 129Xe Ventilation

Fei Tan1, Rachel L. Eddy2,3, Vanessa M. Diamond2, Jonathan H. Rayment2,4, and Peder E. Z. Larson1,5
1UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, San Francisco, CA, United States, 2BC Children's Hospital Research Institute, Vancouver, BC, Canada, 3Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada, 4Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 5Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Lung, LungThis abstract compares the 3D UTE 1H ventilation calculated from Motion-Compensated Low-Rank constrained reconstruction (MoCoLoR) with the hyperpolarized 129Xe ventilation for validation. The dataset covers healthy volunteers and pediatric and adult patients with cystic fibrosis (CF). We validated that 3D UTE 1H has a positively correlated VDP with the gold standard 129Xe and a high spatial VDP accuracy.

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