Keywords: Lung, Hyperpolarized MR (Gas)A filter exchange imaging (FEXI) sequence was developed for studying dynamic changes of apparent diffusion coefficient (ADC) in hyperpolarized 129Xe MRI, thereby probing heterogeneity and connectivity of lung airspaces. The sequence was tested in healthy volunteers and patients of chronic obstructive pulmonary disease (COPD). An initial reduction of ADC after filter application was observed in all subjects. Relative reduction and recovery rate tended to be increased in COPD. Weak/moderate correlations of initial reduction and recovery rate with ADC before filter application were observed. 129Xe FEXI lung MRI is feasible and derived quantities may be useful for disease phenotyping in COPD.
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