Keywords: Lung, LungDirecting treatment based on diagnosis is important in patients suffering with respiratory disease. This work investigated the ability of whole-lung mean T1 and M0, and measures of heterogeneity (median coefficient of variation and its interquartile range) to differentiate between patients with asthma and/or COPD and correlated these metrics with 129Xe ventilation and diffusion MRI and pulmonary function test metrics. Measures of heterogeneity of T1 and M0 correlated with lung function test outcomes and sensitive measures of lung function derived from 129Xe MRI and had the ability to separate patients with asthma+COPD and COPD from patients with asthma alone.
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