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Abstract #4837

Imaging reactive oxygen species and tissue iron in ischemia-reperfusion injury in swine with multimodal [18F]ROStrace PET/CT and QSM

Sophia Swago1, Elizabeth W. Thompson1, Annefleur Loth2, Abhijit Bhattaru3, Brianna F. Moon1, Giovanni Ferrari4, Estibaliz Castillero4, Victor A. Ferrari5, Robert Gorman6, Cory Tschabrunn7, Robert Mach3, Joel Karp3, Walter R. Witschey3, and Paco Bravo3
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Amsterdam Medical Centre, University of Amsterdam (AMC-UvA), Amsterdam, Netherlands, 3Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Surgery, Columbia University, New York City, NY, United States, 5Department of Medicine and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States, 6Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States, 7Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Myocardium, Ischemia

Additional myocardial injury can occur after reestablishing blood flow post ischemia. We use a multimodal protocol of sequential quantitative susceptibility mapping and positron emission tomography to directly image reactive oxygen species (ROS) and tissue iron in vivo in pig hearts after ischemic injury. We found that ROS was increased in infarct compared to remote regions of the myocardium in all animals. In an animal with microvascular obstruction, we observed an increase in susceptibility measured by QSM in the infarct region, indicating increased tissue iron, but no increased susceptibility was seen in the animals without microvascular obstruction.

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