Keywords: Myocardium, IschemiaLate gadolinium enhancement (LGE) is considered the gold standard for the quantification of scar size. We tested in a large animal model of acute and chronic infarction if clinically used methods for the assessment of infarct size (manual planimetry and several semi-automatic approaches) in LGE images are applicable to preclinical 7T LGE imaging of porcine hearts. We found excellent intra-observer reproducibility for all methods. The tested semi-automatic methods performed differently on magnitude (MAG) and phase-sensitive inversion recovery (PSIR) images. Overall, infarct sizes measured in in vivo scans showed good correlation to ex vivo LGE measurements.
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