Abstract #4846

1H NMR of downfield metabolites in swine heart after myocardial infarction

Sophia Swago¹, Jacob Smothers², Neil E. Wilson³, Mark A. Elliott³, Ravi Prakash Reddy Nanga³, Robert Gorman⁴, Cory Tschabrunn⁵, Arjun Sengupta⁶, Aalim Weljie⁶, Ravinder Reddy³, and Walter R. Witschey³

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Chemistry, West Virginia University, Morgantown, WV, United States, ³Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ⁶School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Myocardium, SpectroscopyGrowing interest into in vivo 1H MRS of downfield metabolites (>4.7 ppm) has necessitated greater understanding of the metabolite contributions of peaks found in the downfield. 1H NMR provides high-SNR, high-spectral resolution data that can aid in the identification of metabolite resonances. We collected downfield NMR spectra at 700 MHz from infarct and remote myocardium extract of pig hearts after myocardial infarction. We were able to assign peaks to NAD+, NADH, ATP, and AMP in the downfield region and quantified these metabolites in infarct and remote myocardium.

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