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Abstract #4854

Impact of Epicardial Adipose Tissue Assessed on Early Left Atrial Dysfunction in Heart Failure with Preserved Ejection Fraction

Yunling Li1, Shengliang Liu1, Jianxiu Lian2, Goukun Wang1, Xia Gu1, Yong Sun1, and Bo Yu1
1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China, HarBin, China, 2Phillips Healthcare, Beijing, China

Synopsis

Keywords: Heart, Cardiovascular, Heart failure

Heart failure with preserved ejection fraction (HFpEF) characterized by heart diastolic dysfunction. Epicardial adipose tissue (EAT) has been speculated to play an important role in HFpEF pathophysiological processes. In present study, EAT volume was significantly increased in patients with HFpEF and patients with high risk for developing HFpEF compared with healthy controls, and it was correlated with CMR parameters indicative of diastolic dysfunction, particularly GLS and LA reservoir, conduit, and pump strains. These findings provided compelling evidence for the potential role of EAT in adverse myocardial remodeling and the pathophysiology of HFpEF.

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Keywords