Abstract #4866

Left ventricular layer-specific strain predicts pulmonary arterial hypertension long-term prognosis

Wen Li¹, Xianchang Zhang², Jens Wetzl³, Qing Gu⁴, and Jianguo He⁵

¹State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²MR Collaboration, Siemens Healthineers Ltd, Beijing, China, ³Magnetic Resonance, Siemens Healthcare, Erlangen, Germany, ⁴Emergency Center, State Key Laboratory of Cardiovascular Disease, Key Laboratory of Pulmonary Vascular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁵Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Heart, Data Processing, StrainStudies have reported left ventricular (LV) dysfunction was associated with more severe disease and poorer prognosis in pulmonary arterial hypertension (PAH). However, there are only few studies that evaluated LV strain abnormalities using cardiovascular magnetic resonance (CMR) in PAH patients. This is the first study to describe the distribution pattern and prognostic values of LV layer-specific strain/strain rate in PAH patients using a deformation registration algorithm (DRA) based on CMR. It’s found that CMR derived LV layer-specific strain could predict long-term prognosis in PAH patients.

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