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Abstract #4872

Dependency of R2 and R2* on Gd-DTPA Concentration: From Whole-Blood to Realistic Brain Tumor Vasculature

Daniëlle van Dorth1, Ahmad Alafandi2, Krishnapriya Venugopal2, Aurélien Delphin3, Dirk H. J. Poot2, Thomas Christen3, Marion Smits2,4,5, Jeroen de Bresser6, Juan Hernandez Tamames2, and Matthias J. P. van Osch1,4
1C. J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, 3University Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, Grenoble, France, 4Medical Delta, Delft, Netherlands, 5Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands, 6Radiology, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Keywords: Simulations, DSC & DCE Perfusion

In quantitative DSC-MRI, the concentration-time course is obtained from the MR signal changes following a bolus injection of contrast agent. The generally assumed linear relationship between ΔR2* and contrast agent concentration is not always valid. In this study a realistic 3D simulation model was used to establish the characteristics of this relationship in whole-blood and brain tumor tissue. The results show an improved performance of the 3D simulation model compared to its 2D version. In addition, the relationship between ΔR2* and contrast agent concentration appeared to be dependent on the B0 direction and MR sequence.

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Abstract Presentation Video

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