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Abstract #4875

Towards cell-size and switchable magnetocaloric MRI contrast agents using micofabricated thin-film FeRh.

Stephen Dodd1, Natalia Gudino1, O Zadorozhnii2, M Staňo2, J Hajduček2, J. A. Arregi2, Vojtech Uhlíř2, H. Doug Morris3, Mladen Barbic4, and Alan Koretsky1
1Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States, 2Ceitec Magnetism, Central European Institute of Technology, Brno, Czech Republic, 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 4NYU Langone Health - Tech4Health Institute, New York, NY, United States

Synopsis

Keywords: Contrast Agent, Cell Tracking & Reporter Genes, Magnetocaloric materialWe present progress towards smaller magnetocaloric samples, that drastically change magnetic moment and hence T2* contrast when switched with external magnetic field or temperature, with the eventual goal of achieving a size appropriate for cell tracking. To that end a FeRh sample was microfabricated with a thickness of 200 nm, and patterned with varying linear dimensions from 500 micron down to 1 micron square. We demonstrate that this sample may be switched with temperature and with external field through imaging at 4.7 and 11.7T and with the application of pulsed B0 insert coil.

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