Abstract #4877

Resting perfusion measures in patients with steno-occlusive disease; comparing two contrast agents Gadolinium and hypoxia-induced dOHb

Ece Su Sayin¹, Vittorio Stumpo², Jacopo Bellomo², Julien Poublanc³, Marco Piccirelli⁴, James Duffin¹, Vepeson Wijeya ³, Athina Pangalu⁴, Andrea Bink⁴, Bence Nemeth ⁴, Zsolt Kulcsar⁴, David John Mikulis³, Joseph Arnold Fisher¹, Olivia Sobcyzk ³, and Jorn Fierstra ²

¹Physiology, University of Toronto, Toronto, ON, Canada, ²Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland, ³University Health Network, Toronto, ON, Canada, ⁴Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Contrast Agent, PerfusionDynamic susceptibility contrast perfusion imaging is clinically acquired using Gadolinium based contrast agents (GBCA), however, there remain many drawbacks. We show that in patients with steno-occlusive disease perfusion imaging using hypoxia-induced dOHb have a high degree of similarity to those obtained using GBCA.

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