Keywords: Contrast Agent, Relaxometry, GBCA, gadolinium, long-term deposition, GAGs, dextran sulfate
Detailed biochemical information on the long-term deposition of Gd3+ in the body after administration of GBCAs is still missing. Glycosaminoglycans should be considered as chelators of released Gd3+. We used dextran-sulfate to study the effect of polysaccharides with different molecular weights on the observable relaxivity. Chelation was observed through an increase in relaxation. Moreover, a molecular weight-specific shielding revealed by subsequent reduced R1 occurs at higher polysaccharide/Gd-ion ratios. This coincided with observations of Gd-induced aggregation. Similar shielding of re-chelated Gd3+can lead to an underestimation of deposited Gd-ions in the body and requires further research.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords