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Abstract #4880

First Results of Novel Contrast Agent Based on Ultrasmall Paramagnetic Nanoparticles for T1-Weighted MRI

Khallil Taverna Chaim1, Mayara Klimuk Uchiyama1,2, Robson Raphael Guimaraes2, Koiti Araki2, and Claudia da Costa Leite 1
1School of Medicine - Radiology, University of Sao Paulo, Sao Paulo, Brazil, 2Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil

Synopsis

Keywords: Contrast Agent, Contrast Agent, nanoparticlesMRI is one of the best imaging techniques in clinical analysis because it is non-invasive and has high resolution. Contrast agents are used to further improve these images, as they increase the level of soft tissue detail, differentiating regions of interest. Currently, Gd-based contrast agents have important precautions. In this work we present a new nanoparticle based on iron oxide, with 4 nm and positive contrast (T1-weighted). Thus, effects similar to gadoteric acid, with reduced signal persistence and partial renal excretion, indicating great stability, this new paramagnetic nanoparticle has great potential to be applied as a contrast agent in MRI.

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Keywords