Abstract #4883

Relaxation Rate MR Contrast of Metal-Organic Framework or USPIO Labelled Melt Electrowritten Polycaprolactone Scaffolds

Geoffrey J. Topping¹, Salma Mansi², Kilian M. A. Müller², Zahid Hussain³, Sarah Dummert³, Carolin Rickert⁴, Sebastian P. Schwaminger⁵, Younzhe Zou², Diana M. Rojas-González², Sonja Berensmeier⁵, Oliver Lieleg⁴, Roland Fischer³, Petra Mela², and Franz Schilling¹

¹Department of Nuclear Medicine, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ²Medical Materials and Implants, Department of Mechanical Engineering, TUM School of Engineering and Design, & Munich Institute of Biomedical Engineering, Technical University of Munich, Garching, Germany, ³School of Natural Sciences and Catalysis Research Center, Technical University of Munich, Garching, Germany, ⁴Biomechanics, Department of Materials Engineering, TUM School of Engineering and Design, Technical University of Munich, Garching, Germany, ⁵Chair of Bioseparation Engineering, School of Engineering and Design, Technical University of Munich, Garching, Germany

Synopsis

Keywords: Contrast Mechanisms, Preclinical, Tissue Engineering

Polycaprolactone scaffolds were melt electrowritten with and without included metal-organic frameworks (MOF) or nanoparticles (USPIO). MR images and relaxation rate (R1, R2, R2*) maps were acquired of scaffolds in agar and blood. Pure polycaprolactone showed weak or no contrast. Addition of MOF or USPIOs produced strong T2* contrast. Tensile properties were preserved up to 0.2 w/w% USPIOs. MOFs produced strong w/w% dependent antibacterial effects when included in scaffolds.

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