Abstract #4886

A dedicated arterial input function compensating for inflow and partial voluming in dynamic contrast enhanced MRI

Chih-Hsien Tseng¹, Martijn Nagtegaal¹, Jaap Jaspers², Alejandra Mendez Romero², Piotr Wielopolski³, Marion Smits^3,4, Matthias J.P. van Osch^4,5, and Frans Vos^1,3,4

¹Imaging Physics, Delft University of Technology, Delft, Netherlands, ²Radiation Oncology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands, ³Radiation and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Medical Delta, Delft, Netherlands, ⁵Radiology, C.J. Gorter MRI center, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Keywords: Contrast Mechanisms, DSC & DCE PerfusionBoth inflow and partial volume effects (PVE) are sources of error when measuring the arterial input function (AIF) in DCE-MRI. We proposed a method that estimated the perceived pulse number of spins, and then corrected with these such that both effects were simultaneously compensated. Simulation data demonstrated that the reconstructed AIFs showed only marginal bias. In addition, the algorithm yielded highly correlated reconstructed curves over a wide range of PVEs in clinical data. Our findings show that the PVE can be compensated by considering it as part of the inflow correction as it exhibits similar confounding effects when measuring DCE-AIFs.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.