Abstract #4888

The magnetic resonance characteristics of SPIONs for imaging at ultralow field (6.5 mT)

Sheng Shen¹, David E. J. Waddington², Marie Zhang³, and Matthew S. Rosen^1,4,5

¹MGH/A. A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²The University of Sydney, Sydney, Australia, ³Imagion Biosystems, Ltd, San Diego, CA, United States, ⁴Department of Physics, Harvard University, Cambridge, MA, United States, ⁵Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Contrast Agent, ModellingCharacterization of the parameters of superparamagnetic iron oxide nanoparticles (SPIONs) can guide synthesis of optimized particles for use in magnetic resonance imaging (MRI). With a goal of application of SPIONs in ultra-low field (ULF) MRI, we investigated the properties of SPIONs, and conducted imaging on a 6.5 mT MRI scanner. Specifically, we measured the NMR relaxivity and susceptibility of different SPIONs sample, both dominated by the core size of SPIONs. We also implemented susceptibility imaging using an bSSFP sequence to obtain positive contrast images of SPION phantoms, and present here a method to optimize the ULF susceptibility MRI images.

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