Abstract #4892

**Correction of macroscopic field variation confounding R2* maps in UK Biobank: simulations and preliminary results in phantom**

Chaoyue Wang^1,2, Aaron T. Hess¹, William T. Clarke¹, Stuart Clare¹, Diego Hernando³, Scott B. Reeder³, Karla L. Miller¹, and Benjamin C. Tendler¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University Of Oxford, Oxford, United Kingdom, ²SJTU-Ruijin-UIH Institute for Medical Imaging Technology, Shanghai, China, ³Departments of Radiology, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Electromagnetic Tissue Properties, Electromagnetic Tissue PropertiesOur results suggest that R2* maps in UK Biobank are confounded by the macroscopic field variation which leads to spurious associations driven by field variations due to the air/tissue interfaces. This effect can be modeled as a signal modulation which can be removed through a voxel-wise correction.

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