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Abstract #4892

Correction of macroscopic field variation confounding R2* maps in UK Biobank: simulations and preliminary results in phantom

Chaoyue Wang1,2, Aaron T. Hess1, William T. Clarke1, Stuart Clare1, Diego Hernando3, Scott B. Reeder3, Karla L. Miller1, and Benjamin C. Tendler1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University Of Oxford, Oxford, United Kingdom, 2SJTU-Ruijin-UIH Institute for Medical Imaging Technology, Shanghai, China, 3Departments of Radiology, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Electromagnetic Tissue Properties, Electromagnetic Tissue PropertiesOur results suggest that R2* maps in UK Biobank are confounded by the macroscopic field variation which leads to spurious associations driven by field variations due to the air/tissue interfaces. This effect can be modeled as a signal modulation which can be removed through a voxel-wise correction.

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