Abstract #4896

Monte Carlo simulations of transverse relaxation for assessing physico-chemical properties of novel superparamagnetic iron oxide particles

Lauritz Klünder¹, Bastian Maus¹, Maria Belen Rivas Aiello², Thomas Kirse^3,4, Cristian Strassert^3,4, and Cornelius Faber¹

¹Clinic of Radiology, University of Münster, Münster, Germany, ²Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, Universidad Nacional de La Plata - CONICET, La Plata, Argentina, ³Institut für Anorganische und Analytische Chemie, University of Münster, Münster, Germany, ⁴CeNTech, CiMIC, SoN, University of Münster, Münster, Germany

Synopsis

Keywords: Relaxometry, Contrast Agent, Simulations

Physico-chemical properties of superparamagnetic iron oxide nanoparticles (IONP) strongly affect their impact on transverse relaxation and their efficiency as MR contrast agents. Monte Carlo simulations were developed to model relaxation in silico for two novel IONPs with distinct physico-chemical properties. The IONPs comprised an identical magnetite core but differed in preparation strategy, defining their coating and size. Simulations were compared to in vitro relaxometry measurements and reproduced experimentally measured relaxation times. Using lognormally distributed particle radii in the simulations was required to obtain correct R₂^* values. Together, simulations and measurements unveiled additional particle aggregation in the MR samples.

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