Abstract #4897

In Vivo Single Voxel Relaxation-Diffusion Correlation Spectra Revealed the Microstructure of Human Brain

Lixian Wang^1,2, Tomohisa Okada³, Takashi Hanakawa^1,3, Baogui Zhang^2,4, Huilou Liang², Jing An⁵, Rong Xue^2,4,6, and Fangrong Zong^2,7

¹Department of Integrated Neuroanatomy and Neuroimaging, Kyoto University, Kyoto, Japan, ²Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ³Human Brain Research Center, Kyoto University, Kyoto, Japan, ⁴University of Chinese Academy of Sciences, Beijing, China, ⁵Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁶Beijing Institute for Brain Disorders, Beijing, China, ⁷School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China

Synopsis

Keywords: Multi-Contrast, Diffusion/other diffusion imaging techniques

Multidimensional MRI resolves the correlations between physical parameters and relaxation properties and has become an increasingly important protocol in biomedical engineering. It has sub-voxel resolution but most research still uses multi-voxel ROIs. In this study, we obtained the single voxel T₁-D Relaxation-Diffusion correlation spectra from in vivo human brain tissue boundaries. The significant variance in these spectra might help to identify tissue microstructure at the sub-voxel resolution. Our research disclosed the feasibility of applying multidimensional MRI techniques to detect and segment the human brain.

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