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Abstract #4903

Whole Brain R2 Maps at 7T Highlight Iron-Rich Cortical Gray and Sub-cortical White Matter

Yicun Wang1, Peter van Gelderen1, Jacco de Zwart1, and Jeff H. Duyn1
1AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States

Synopsis

Keywords: Relaxometry, Relaxometry, T2 mapping; IronGradient Echo Sampling of Spin Echo signal was used to obtain whole-brain R2 maps from 8 young and 1 senior healthy volunteers at 7T. Cortical surface reconstruction showed increased R2 in areas of high iron content as known from histology. Furthermore, high R2 in sensory-motor and visual cortices was accompanied by low R2 in underlying white matter. Highest R2 in subcortical white matter was found in frontal and temporal lobes. The low sensitivity of R2 to fiber orientation and venous vasculature may render it more suitable than R2* and $$$\chi$$$ for iron quantification, especially near the brain surface.

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Keywords