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Abstract #4904

B1 and B0 insensitive R1σ preparation pulses can reduce sensitivity to R1σ dispersion

Kevin D Harkins1,2,3, Jason Ostenson1,2, Fatemeh Adelnia1,2, Feng Wang1,2, Zhongliang Zu1,2, and John C Gore1,2,3
1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Relaxometry, SimulationsR1σ dispersion imaging can be used to uncover specific relaxation mechanisms in soft tissues, but is sensitive to B0 and B1 inhomogeneity. Several varieties of R1σ preparation pulses have been developed to reduce sensitivity to B0 and B1, typically by introducing a spin echo or double spin echo as part of the preparation pulse. This simulation study shows that such pulses can actually reduce the sensitivity to R1σ dispersion.

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