Abstract #4927

Quantification of gray matter abnormalities in drug‑naïve major depressive disorders by synthetic MRI

Junyan Wen¹, Shanshan Yang¹, Xuecong Lin¹, Wei Cui², Long Qian², Zhimin Chen¹, Liaoming Gao¹, Qian Gao³, Weikang Huang ⁴, Dongliang Cheng⁵, and Ge Wen¹

¹Medical Imaging Department, Nanfang Hospital, Guangzhou, China, ²MR Research, GE Healthcare, Beijing, China, Beijing, China, ³Department of Radiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China, ⁴Department of Radiology, Zengcheng Branch of Nanfang Hospital, Guangzhou, China, ⁵Department of Radiology, First People's Hospital of Foshan, Foshan, China

Synopsis

Keywords: Psychiatric Disorders, Brain, Major depressive disorderMajor depressive disorder (MDD) is a common mental illness. Herein, we explored the differences in the whole-brain T1 and T2 relaxation times between drug-naïve major depressive disorder patients and healthy controls by synthetic MRI (SyMRI). The results showed altered T1 and T2 values in specific regions of the gray matter in MDD patients, which may be associated with alterations in the brain gray matter microstructure, such as excessive iron deposition. Thus, these quantitative variables may be promising imaging markers for further exploring the pathophysiological mechanisms of depression.

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