Abstract #4928

Sex Difference of Hippocampal Subfields in First-episode Drug-naive Patients with Major Depressive Disorder

Mengyue Tang¹, Lianqing Zhang¹, Zilin Zhou¹, Lingxiao Cao¹, Yingxue Gao², Hailong Li², Xinyue Hu¹, Kaili Liang², Weijie Bao², Yingying Wang¹, Weihong Kuang², Qiyong Gong¹, and Xiaoqi Huang²

¹Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China., Chengdu, China, ²Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China., Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, BrainWe investigated hippocampal subfields volumes in a relatively large sample of first-episode drug-naive MDD and explored sex-related effects. We used Freesurfer software to segment the hippocampus with longitudinal axis and transverse axis automatically. We found there were different alterations of hippocampus along different axis. The sex-independent decreased volume of hippocampal and its subregions along the longitudinal, while the sex specific alteration only detected in the subfields along the transverse axis. These current findings may interpretate the hippocampus appears to have functional segregation along the different axis, which may contribute to developing new diagnostic and mechanism of sex difference for MDD.

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