Abstract #4931

Abnormal dynamic function connectivity pattern in first-episode, drug-naïve adult patients with major depressive disorder

Tao Chen¹, Zhongyi He², Qinger Guo¹, Jinfeng Duan³, Yong Zhang⁴, Min Wang², and Hong Yang¹

¹Radiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ²College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ³Psychiatry, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ⁴GE Healthcare, Shanghai, China

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state)

Objective: To explore the specific FC change patterns of MDD by combining sFC and dFC.

Methods: 37 MDD and 36 matched HCs were included in this study. The differences of sFC and dFC between two groups were compared.

Results: Compared to HCs, patients showed less time in the anti-correlated state between higher-order and lower-order networks and longer dwell time in the whole-brain weakly connected state. The mean dwell time of state 4 was negative correlation with the behavioral scale score in patients.

Conclusions: These disrupted dFC patterns provide new clues to understanding the neuropathology of state-dependence in MDD.

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