Abstract #4932

Evaluation of different multi-echo combinations on objective depression prognosis in an emotional face-matching task

Jesper Pilmeyer^1,2, Rolf Lamerichs^1,3, Faroeq Rahmat Ramsaransing^1,2,4, Marcel Breeuwer^1,5,6, and Svitlana Zinger^1,2

¹Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ²Department of Research and Development, Epilepsy Centre Kempenhaeghe, Heeze, Netherlands, ³Philips Research, Eindhoven, Netherlands, ⁴Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁶Philips Healthcare, Best, Netherlands

Synopsis

Keywords: Psychiatric Disorders, fMRI (task based), Multi-echo imagingObjective prognosis of major depressive disorder (MDD) based on functional MRI (fMRI) biomarkers remains problematic due an abundance of physiological and motion confounders. Multi-echo imaging enhances the BOLD sensitivity while reducing signal loss. Here, we evaluate the effect of different multi-echo combinations on MDD symptom improvement prediction in an emotional face-matching fMRI task. We demonstrate improved signal quality and activation contrast for multi-echo combinations in the amygdala and hippocampus and predict 3-months and 6-months MDD symptom improvement with 91% and 87% accuracy, respectively. These results highlight the benefits of novel multi-echo acquisitions for prognosis in psychiatric disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.