Abstract #4933

The Hippocampus-Amygdala Complex Show Altered Structural Covariance Properties in Never-treated Patients with First-Episode Depression

Lianqing Zhang¹, Xinyue Hu¹, Mengyue Tang¹, Hui Qiu¹, Yongbo Hu¹, Yingxue Gao¹, Hailong Li¹, Weihong Kuang², and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, PR ChinaMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, Neuroscience, hippocampus, amygdalaThe hippocampus and amygdala are densely interconnected structures that work together in multiple affective and cognitive processes that are important to the etiology of major depressive disorder. By constructing a network based on the volumetric covariation among subfields/subregions within the hippocampus-amygdala complex, we found the topologic properties within localized network of the hippocampus-amygdala complex were disrupted in never-treated patients with first-episode depression. The current study provided the first evidence of atypical structural covariance network within the hippocampus-amygdala complex in patients with early stage of MDD, which could be a potential biomarker in the future psychoradiological practices.

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