Abstract #4934

Glymphatic system dysfunction in patients with major depressive disorder

Shanshan Yang¹, Xuecong Lin¹, Junyan Wen¹, Wei Cui², Long Qian², Weiwei Cui¹, Ziqi Wu¹, Peiqian Hu³, Liyang Yang⁴, and Ge Wen¹

¹Medical Imaging Department, Nanfang Hospital, Guangzhou, China, ²MR Research, GE Healthcare, Beijing, China, Beijing, China, ³Department of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China, ⁴Department of Radiology, Zengcheng Branch of Nanfang Hospital, Guangzhou, China

Synopsis

Keywords: Psychiatric Disorders, Brain, Major depressive disorderMajor depressive disorder (MDD) is a severe mental sickness. Yet, its neural mechanisms remain unclear. The present study aimed to analyze the different degrees of glymphatic system activity between patients with MDD and healthy controls using diffusion tension imaging (DTI) along the perivascular space (DTI-ALPS). The results showed that the patients with MDD had glymphatic system dysfunction, which increases anxiety. Thus, the ALPS index is expected to be a biomarker for monitoring changes in glymphatic system function in MDD patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.