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Abstract #4936

Effect of acute ketamine on vigilance measured by multi-echo fMRI in treatment resistant major depression

Jennifer Evans1 and Carlos Zarate1
1NIH, Bethesda, MD, United States

Synopsis

Keywords: Psychiatric Disorders, Drugs, major depression, ketamineWe investigate vigilance changes during intravenous ketamine administration in patients with treatment resistant major depression using an fMRI arousal template. There is a significant decrease in the average vigilance index after ketamine infusion as compared to placebo. The fMRI based vigilance index shows promise in detecting the rapid onset of ketamine administration effects.

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Keywords