Abstract #4938

Prefrontal glutathione levels in major depressive disorder are linked to a loss of positive mood

Ruth O'Gorman Tuura¹, Andreas Buchmann^2,3, Christopher Ritter^2,3, Melanie Haynes⁴, Ralph Noeske⁵, and Gregor Hasler³

¹University Children's Hospital Zurich, Zurich, Switzerland, ²Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland, ³Psychiatry Research Unit, University of Fribourg, Fribourg, Switzerland, ⁴Translational Research Center, University Hospital of Psychiatry and Psychotherapy, Bern, Switzerland, ⁵GE Healthcare, Munich, Germany

Synopsis

Keywords: Psychiatric Disorders, SpectroscopyMajor depressive disorder (MDD) is one of the most common neuropsychiatric disorders, with symptoms including persistent sadness and low mood. MDD is associated with neurochemical alterations in GABA, glutamate, and glutamine levels, but to date few studies have examined changes in glutathione (GSH) in MDD. This study investigated changes in GSH in a medication naïve group of participants with current and past depression, and healthy controls, and the link between GSH, stress markers, depressive symptoms and mood. We observed elevated prefrontal GSH in participants with current but not remitted depression, which was associated with a decrease in positive mood.

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