Abstract #4941

Quantitative Study of Brain Iron Deposition in Major Depression Disorder

Bo Zhou¹, Wenjia Liang², Chenxi Sun², Wenjun Wang², Weiqiang Dou³, Dmytro Pylypenko³, Huimin Hou⁴, and Bao Wang¹

¹Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, ²Department of Anatomy and Neurobiology, Cheeloo College of Medicine, Shandong University, Jinan, China, ³MR Research China, GE Healthcare, Beijing, China, ⁴Department of Orthopedic Surgery, Qilu Hospital of Shandong University, Jinan, China

Synopsis

Keywords: Psychiatric Disorders, Quantitative Susceptibility mappingThe occurrence of depression may be related to the accumulation of iron in the brain. T1-weighted images were linearly registered into the QSM space, and then six regions of interest (ROIs) were obtained using the automated segmentation pipeline. Susceptibility values of major depression disorder (MDD) and healthy control (HC) groups were compared using the two-sided Student's t-test. The susceptibility of the left amygdala and right putamen in MDD patients were significantly increased, and positively correlated with the severity of depression and insomnia, respectively. The increased iron in the left amygdala may be a new biomarker for MDD.

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