Abstract #4942

White matter alterations in patients with major depressive disorder: A Quantitative synthetic MRI Study

Junyan Wen¹, Shanshan Yang¹, Xuecong Lin¹, Wei Cui², Long Qian², Zhimin Chen¹, Liaoming Gao¹, Qian Gao³, Weikang Huang ⁴, Dongliang Cheng⁵, and Ge Wen¹

¹Medical Imaging Department, Nanfang Hospital, Guangzhou, China, ²MR Research, GE Healthcare, Beijing, China, Beijing, China, ³Department of Radiology, the First Affiliated Hospital of Kunming Medical University, Kunming, China, ⁴Department of Radiology, Zengcheng Branch of Nanfang Hospital, Guangzhou, China, ⁵Department of Radiology, First People's Hospital of Foshan, Foshan, China

Synopsis

Keywords: Psychiatric Disorders, Brain, Major depressive disorder; white matter microstructureMajor depressive disorder (MDD) is a severe mental disorder with unclear pathophysiology mechanism. The present study aimed explore white matter (WM) microstructure alterations in MDD patients using synthetic MRI technique. The results showed shorter T1 relaxation time in several deep WM regions, while extensive myeline content was found in left anterior limb of internal capsule in patients with MDD. Thus, we concluded that WM alterations caused by MDD can be revealed by quantitative MRI parameters.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.