Abstract #4945

Assessment of Oxidative Stress and Neuronal Activity Affected in PTSD Subjects

Antonia Susnjar¹, Gianna Nossa², Joseph V Rispoli¹, Ulrike Dydak^2,3, and Meden Issac-Lam⁴

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²School of Health Sciences, Purdue University, West Lafayette, IN, United States, ³Department of Radiology and Imaging Sciences, Indiana School of Medicine, Indianapolis, IN, United States, ⁴Department of Chemistry and Physics, Purdue Northwest University, Hammond, IN, United States

Synopsis

Keywords: Psychiatric Disorders, Trauma, PTSDWe are reporting neurometabolic imbalances in post-traumatic stress disorder using edited and unedited single voxel spectroscopy with optimized HERMES data acquisition at 3T. We have investigated five brain regions that play a significant role in PTSD including insula, hippocampus, amygdala, anterior, and dorsolateral prefrontal cortex. Our findings report the largest metabolic concentration changes in amygdala which moderates flight or fight state. Moreover, we observe decrease of primary neurotransmitter GABA in hippocampus, antioxidant GSH in DLPFC, and membrane turnover marker tCho across all brain regions.

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