Abstract #4946

Neurochemical effects of intrusive thinking in pathological and non-pathological worriers: A combined MRS, functional connectivity study

Antonio Napolitano¹, Martino Schettino^2,3, Chiara Parrillo¹, Giulia Baldassari¹, Luca Cairone¹, Salvatore Gazzellini¹, Federico Giove^3,4, and Cristina Ottaviani^2,3

¹Bambino Gesù Pediatric Hospital, Rome, Italy, ²Sapienza University of Rome, Rome, Italy, ³IRCCS Santa Lucia Foundation, Rome, Italy, ⁴Centro Ricerche Enrico Fermi, Rome, Italy

Synopsis

Keywords: Psychiatric Disorders, Brain, Spectroscopy; GABA; Glx

The present study combined magnetic resonance spectroscopy, resting state functional connectivity and ecological momentary assessment to support the view that intrusive thinking may be pathologically maintained via negative reinforcement, namely a reduction in autonomic arousal that prevents the transition from a relaxed state to a spike of activation.

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