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Abstract #4991

Sparse regression-based delineation of air-motion artifacts for real-time correction of PRFS thermometry

Sven Nouwens1, Maarten Paulides2,3, and Maurice Heemels1
1Mechanical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Radiotherapy, Erasmus MC, Rotterdam, Netherlands

Synopsis

Keywords: Sparse & Low-Rank Models, Thermometry, susceptiblity aritfact correctionProton resonance frequency shift-based MR thermometry is widely used to non-invasively monitor thermal therapies in vivo. However, further clinical integration in deep hyperthermia is hampered by intestinal air-motion induced susceptibility artifacts. We developed a sparse regression approach to delineate susceptibility artifact sources. The resulting mask is then used to correct the artifact using existing methods from quantative susceptibility mapping. We verified our approach by a heated phantom experiment equipped with a moveable air volume and temperature probes. Here, we found a reduction in the mean absolute error from 1.6 degrees Celsius to 0.4 degrees Celsius, near the air-motion artifact.

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