Abstract #5001

Real-time automatic temperature regulation during in-vivo MRI-guided Laser-induced Thermo-Therapy (MR-LITT)

Manon Desclides^1,2, Valéry Ozenne¹, Pierre Bour², Thibault Faller², Guillaume Machinet³, Christophe Pierre³, Stéphane Chemouny², and Bruno Quesson¹

¹University of Bordeaux, CNRS, CRMSB, UMR 5536, IHU Liryc, Bordeaux, France, Metropolitan, ²Certis Therapeutics, Pessac, France, ³ALPhANOV, Talence, France

Synopsis

Keywords: Interventional Devices, MR-Guided InterventionsThe presented method allows to automatically adjust laser power relying on real-time rapid volumetric MR-thermometry using the proton resonance frequency (PRF) shift technique. The laser output power is regulated every second to force temperature to follow a predefined temperature-time profile using a PID controller, taking MR-temperature data as input. The proposed temperature regulation algorithm is successfully validated in vivo in the skeletal muscle of a pig.

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