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Abstract #5007

Optimized diffusion-prepared 3D-MRF for rapid high-resolution whole-brain T1, T2, proton density, ADC and FA mapping

Xiaozhi Cao1,2, Congyu Liao1,2, Zihan Zhou3, Zheng Zhong1, Zhitao Li1, Erpeng Dai1, Siddharth Srinivasan Iyer1,4, Airel Hannum1,5, Mahmut Yurt1,2, Sophie Schauman1,2, Quan Chen1, Nan Wang1, Yifan Yan3, Hongjian He3, Stefan Skare6, Jianhui Zhong7, Adam Kerr2, and Kawin Setsompop1,2
1Department of Radiology, Stanford university, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford university, Stanford, CA, United States, 3Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 4Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 5Department of Bioengineering, Stanford university, Stanford, CA, United States, 6Department of Clinical Neuroscience, Karolinska Institute, Solna, Sweden, 7Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, BrainIn this work, a diffusion preparation was implemented into the 3D spiral-projection MRF sequence to introduce additional diffusion weighting and enables whole-brain T1, T2, PD, ADC and FA mapping with 1-mm isotropic resolution within 10min. To maximize the diffusion signal and image-encoding efficiency, a diffusion-preparation without an amplitude stabilizer is employed, where robustness against phase variations is achieved using a combination of M1-compensated encoding, cardiac-gating, and an eddy-current compensating pre-pulse gradient. The MRF acquisition scheme and subspace reconstruction were also modified to enable effective data sharing across diffusion directions, which increase acceleration capability and improve mapping quality.

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