Abstract #5018

Improving in vivo MR g-ratio mapping via calibration of linearly transformed MR markers from in situ to ex vivo

Jan Malte Oeschger¹, Francisco Javier Fritz¹, Mohammad Ashtarayeh², Maria Morozova^3,4, Tobias Streubel¹, Henriette Rusch⁴, Markus Morawski^4,5, Nikolaus Weiskopf^5,6, and Siawoosh Mohammadi^1,5

¹Department of Systems Neurosciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Department of Systems Neurosciences,, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Neurophysics,, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany, ⁵Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁶Faculty of Physics and Earth Sciences, Felix Bloch Institute for Solid State Physics, Leipzig, Germany

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Diffusion/other diffusion imaging techniques, G-ratioIn vivo MR g-ratio mapping relies on a calibrated method that relates myelin and axon MR markers to volume fractions. To estimate the calibration parameter, fixed ex vivo tissue measured with MRI and histology is used. The so-determined calibration parameter is then applied in vivo, neglecting the difference in the MR markers due to fixation. Here, we proposed a new calibration method accounting for this difference. The new calibration reduced the variability across MR g-ratios based on different myelin and axon markers, indicating that it can improve the accuracy of MR g-ratios.

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